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Literature summary extracted from

  • Mathew, L.; Beattie, N.; Pritchett, C.; Lanzilotta, W.
    New insight into the mechanism of anaerobic heme degradation (2019), Biochemistry, 58, 4641-4654 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.342 2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin Escherichia coli the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.342 Escherichia coli A0A384LP51
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.342 2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens Escherichia coli S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.342 chuW
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 Escherichia coli

Expression

EC Number Organism Comment Expression
2.1.1.342 Escherichia coli the enzyme is expressed in the enteric pathogen Escherichia coli O157:H7 when iron is limiting up

General Information

EC Number General Information Comment Organism
2.1.1.342 physiological function the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens. The physiological role of the gene cluster (ChuW, ChuX, and ChuY) is the liberation of iron during colonization and infection of the intestine. ChuW catalyzes the anaerobic degradation of heme to release iron and produce a reactive tetrapyrrole termed anaerobilin Escherichia coli